US 12,324,769 B1
Double-network versatile hydrogel with antibacterial and drug sequential release capabilities
Hengrui Zhang, Shandong (CN); Qingjun Zhou, Shandong (CN); Shuqin Meng, Shandong (CN); and Huifang Ren, Shandong (CN)
Assigned to EYE INSTITUTE OF SHANDONG FIRST MEDICAL UNIVERSITY, (CN)
Filed by Eye Institute of Shandong First Medical University, Shandong (CN)
Filed on Oct. 11, 2024, as Appl. No. 18/913,776.
Claims priority of application No. 202311609694.4 (CN), filed on Nov. 29, 2023.
Int. Cl. A61F 9/00 (2006.01); A61L 27/12 (2006.01); A61L 27/18 (2006.01); A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/52 (2006.01)
CPC A61F 9/0017 (2013.01) [A61L 27/12 (2013.01); A61L 27/18 (2013.01); A61L 27/20 (2013.01); A61L 27/227 (2013.01); A61L 27/3687 (2013.01); A61L 27/52 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A preparation method of a double-network versatile hydrogel with antibacterial and drug sequential release capabilities, comprising the following steps:
(1) mixing 4-(4-hydroxymethyl-2-methoxy-5-nitrophenoxy) butyric acid, tert-butoxycarbonyl-polyethylene glycol-amino and 1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate in a solvent, and adding trifluoroacetic acid for reaction, and then concentrating and precipitating in a pre-cooled diethyl ether to obtain a precipitate;
(2) re-dissolving the precipitate obtained in step (1), mixing with D/L-lactide, glycoluril and stannous isooctoate, concentrating after a reaction, and precipitating in a pre-cooled diethyl ether to obtain a precipitate;
(3) co-blending the precipitate obtained in step (2) with a drug in a solvent and stirring to obtain drug-loaded micelles; and
(4) mixing methacrylate silk fibroin, glycidyl methacrylate functionalized quaternized chitosan, polydeoxyribonucleotide, and lithium phenyl(2,4,6-trimethylbenzoyl) phosphinate with the drug-loaded micelles, followed by cross-linking under irradiation of ultraviolet to construct the double-network versatile hydrogel with antibacterial and drug sequential release capabilities.