US 12,000,844 B2
Diagnostic drug and diagnostic method for Alzheimer's disease
Atsushi Ono, Osaka (JP); Yasuhiro Teranishi, Osaka (JP); Masanori Kusumoto, Osaka (JP); Masakazu Hashimoto, Osaka (JP); Shoji Kashiwabara, Suita (JP); and Maki Hashimoto, Suita (JP)
Assigned to SUMITOMO PHARMA CO., LTD., Osaka (JP)
Appl. No. 17/265,805
Filed by SUMITOMO PHARMA CO., LTD., Osaka (JP)
PCT Filed Aug. 6, 2019, PCT No. PCT/JP2019/030904
§ 371(c)(1), (2) Date Feb. 3, 2021,
PCT Pub. No. WO2020/032027, PCT Pub. Date Feb. 13, 2020.
Claims priority of application No. 2018-148924 (JP), filed on Aug. 7, 2018.
Prior Publication US 2021/0165002 A1, Jun. 3, 2021
Int. Cl. C07K 16/18 (2006.01); G01N 33/15 (2006.01); G01N 33/531 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/6896 (2013.01) [C07K 16/18 (2013.01); G01N 33/15 (2013.01); G01N 33/531 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An antibody recognizing a S38AA polypeptide, wherein the S38AA polypeptide consists of the amino acid sequence of SEQ ID NO: 1, or an amino acid sequence resulting from substitution, deletion, addition, or insertion of one to several amino acids in the amino acid sequence of SEQ ID NO: 1, and wherein the antibody is
(a) an antibody comprising the heavy chain variable region of SEQ ID NO: 4, and the light chain variable region of SEQ ID NO: 5,
(b) an antibody comprising the heavy chain variable region of SEQ ID NO: 6, and the light chain variable region of SEQ ID NO: 7,
(c) an antibody comprising the heavy chain variable region of SEQ ID NO: 8, and the light chain variable region of SEQ ID NO: 9,
(d) an antibody comprising the heavy chain variable region of SEQ ID NO: 10, and the light chain variable region of SEQ ID NO: 11,
(e) an antibody comprising the heavy chain variable region of SEQ ID NO: 12, and the light chain variable region of SEQ ID NO: 13,
(f) an antibody comprising the heavy chain variable region of SEQ ID NO: 14, and the light chain variable region of SEQ ID NO: 15,
(g) an antibody comprising the heavy chain variable region of SEQ ID NO: 16, and the light chain variable region of SEQ ID NO: 17,
(h) an antibody comprising the heavy chain variable region of SEQ ID NO: 18, and the light chain variable region of SEQ ID NO: 19,
(i) an antibody comprising the heavy chain variable region of SEQ ID NO: 20, and the light chain variable region of SEQ ID NO: 21, or
(j) an antibody comprising the heavy chain variable region of SEQ ID NO: 22, and the light chain variable region of SEQ ID NO: 23.