US 12,000,784 B2
Identification of degradative species
Venkata Velvadapu, Germantown, MD (US); and Mark Mortellaro, Germantown, MD (US)
Assigned to Senseonics, Incorporated, Germantown, MD (US)
Filed by Senseonics, Incorporated, Germantown, MD (US)
Filed on Nov. 13, 2020, as Appl. No. 17/097,678.
Claims priority of provisional application 62/934,599, filed on Nov. 13, 2019.
Prior Publication US 2021/0140888 A1, May 13, 2021
Int. Cl. G01N 21/64 (2006.01); A61B 5/145 (2006.01); A61B 5/1486 (2006.01); G01N 21/78 (2006.01); G01N 33/52 (2006.01); G01N 33/66 (2006.01)
CPC G01N 21/6428 (2013.01) [A61B 5/14532 (2013.01); A61B 5/14865 (2013.01); G01N 33/521 (2013.01); G01N 33/66 (2013.01); A61B 2503/40 (2013.01); G01N 2021/6439 (2013.01)] 34 Claims
 
1. A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
an analyte indicator; and
one or more degradative species probes having absorption and/or emission profiles that are selective for a specific degradative species, wherein the one or more degradative species probes comprise:
(a) a degradative species probe of Formula I:

OG Complex Work Unit Chemistry
(b) a degradative species probe of Formula II:

OG Complex Work Unit Chemistry
(c) a degradative species probe of Formula IV:

OG Complex Work Unit Chemistry
(d) the degradative species probe of the Formula I and the degradative species probe of the Formula II;
(e) the degradative species probe of the Formula II and the degradative species probe of the Formula IV;
(f) the degradative species probe of the Formula I and the degradative species probe of the Formula IV; or
(g) the degradative species probe of the Formula I, the degradative species probe of the Formula II, and the degradative species probe of the Formula IV,
wherein each R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is independently selected from the group consisting of H, C1-C20 alkyl, C1-C20 alkoxy, carboxy, aryl, heteroaryl, polycyclic, alkoxy, halide, SH, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted) amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido.