US 11,999,822 B2
Polyoxazoline copolymer comprising calcium binding groups
Sander Cornelis Gerardus Leeuwenburgh, Nijmegen (NL); Jan Cornelis Maria Van Hest, Nuenen (NL); María José Sánchez-Fernández, Nijmegen (NL); Rosa Pilar Felix Lanao, Nijmegen (NL); Joost Opsteen, Nijmegen (NL); and Johannes Caspar Mathias Elizabeth Bender, Nijmegen (NL)
Assigned to CILAG INTERNATIONAL GMBH, Zug (CH)
Filed by GATT TECHNOLOGIES B.V., Nijmegen (NL)
Filed on Jan. 27, 2022, as Appl. No. 17/586,428.
Application 17/586,428 is a continuation of application No. PCT/EP2020/071317, filed on Jul. 28, 2020.
Claims priority of application No. 19189100 (EP), filed on Jul. 30, 2019.
Prior Publication US 2022/0153930 A1, May 19, 2022
Int. Cl. C08G 73/02 (2006.01)
CPC C08G 73/0233 (2013.01) 13 Claims
OG exemplary drawing
 
1. A polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof,
wherein the copolymer comprises:
(a) repeating units A of formula —[N(Ra)CH2CH2]—;
(b) repeating units B of formula —[N(Rb)CH2CH2]—;
(c) optionally repeating units C of formula —[N(Rc)CH2CH2]—;
(d) optionally repeating units D of formula —[N(Rd)CH2CH2]—; and
(e) optionally repeating units E of formula —[N(Re)CH2CH2]—;
wherein:
Ra is CO—(CHR1)t—H;
Rb is CO—(CHR1)t—CONH—R2—X—CO—(CHR3)u—CONR4—CO-ccr;
R1 represents H or optionally substituted C1-5 alkyl;
R2 represents an optionally substituted C1-5 alkylene;
R3 represents H or optionally substituted C1-5 alkyl;
R4 represents H or CH3;
X represents O, NR11, S or +NR11(R12);
R11 and R12 represent H, methyl or ethyl;
t represents 1, 2 or 3;
u represents 1, 2 or 3; and
ccr represents a calcium binding group.