CPC C08G 73/0233 (2013.01) | 13 Claims |
1. A polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof,
wherein the copolymer comprises:
(a) repeating units A of formula —[N(Ra)CH2CH2]—;
(b) repeating units B of formula —[N(Rb)CH2CH2]—;
(c) optionally repeating units C of formula —[N(Rc)CH2CH2]—;
(d) optionally repeating units D of formula —[N(Rd)CH2CH2]—; and
(e) optionally repeating units E of formula —[N(Re)CH2CH2]—;
wherein:
Ra is CO—(CHR1)t—H;
Rb is CO—(CHR1)t—CONH—R2—X—CO—(CHR3)u—CONR4—CO-ccr;
R1 represents H or optionally substituted C1-5 alkyl;
R2 represents an optionally substituted C1-5 alkylene;
R3 represents H or optionally substituted C1-5 alkyl;
R4 represents H or CH3;
X represents O, NR11, S or +NR11(R12);
R11 and R12 represent H, methyl or ethyl;
t represents 1, 2 or 3;
u represents 1, 2 or 3; and
ccr represents a calcium binding group.
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