	US 11,999,778 B2
	VH4 antibodies and compositions comprising the same
Nancy Monson, Ovilla, TX (US)
Assigned to The Board of Regents of The University of Texas System, Austin, TX (US)
Appl. No. 16/301,187
Filed by The Board of Regents of the University of Texas System, Austin, TX (US)
PCT Filed May 12, 2017, PCT No. PCT/US2017/032411 § 371(c)(1), (2) Date Nov. 13, 2018, PCT Pub. No. WO2017/197265, PCT Pub. Date Nov. 16, 2017.
Claims priority of provisional application 62/336,409, filed on May 13, 2016.
Prior Publication US 2022/0281961 A1, Sep. 8, 2022
Int. Cl. C07K 16/18 (2006.01); A61P 25/28 (2006.01); C12N 15/113 (2010.01)

CPC C07K 16/18 (2013.01) [A61P 25/28 (2018.01); C12N 15/113 (2013.01); C07K 2317/21 (2013.01); C07K 2317/56 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01)]

5 Claims

1. A composition comprising a recombinant human VH4 antibody or antigen-binding portion thereof and an acceptable carrier, wherein the antibody or antigen-binding portion has a set of heavy chain complementarity determining regions (CDRs) as set forth in SEQ ID NO: 19 and a set of light chain CDRs as set forth in SEQ ID NO: 20, and wherein the antibody or antigen-binding fragment binds to an antigen in human gray and/or white matter.