US 11,999,775 B2
VEGF-binding protein for blockade of angiogenesis
Bob Carter, Belmont, MA (US); Jeng-Shin Lee, Lincoln, MA (US); Szofia S. Bullain, Tustin, CA (US); and Richard C. Mulligan, Cambridge, MA (US)
Assigned to Children's Medical Center Corporation, Boston, MA (US); The General Hospital Corporation, Boston, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed by Children's Medical Center Corporation, Boston, MA (US); The General Hospital Corporation, Boston, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed on Mar. 4, 2019, as Appl. No. 16/291,829.
Application 16/291,829 is a continuation of application No. 15/619,917, filed on Jun. 12, 2017, granted, now 10,259,862.
Application 15/619,917 is a continuation of application No. 14/239,687, granted, now 9,701,731, issued on Jul. 11, 2017, previously published as PCT/US2012/051412, filed on Aug. 17, 2012.
Claims priority of provisional application 61/525,278, filed on Aug. 19, 2011.
Prior Publication US 2019/0292239 A1, Sep. 26, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/71 (2006.01); A61K 48/00 (2006.01); C07K 14/475 (2006.01); C12N 15/11 (2006.01); A61K 35/42 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C12N 15/113 (2010.01)
CPC C07K 14/71 (2013.01) [A61K 48/00 (2013.01); C07K 14/475 (2013.01); C12N 15/11 (2013.01); A61K 35/42 (2013.01); A61K 38/00 (2013.01); A61K 39/001109 (2018.08); C07K 2317/24 (2013.01); C07K 2319/30 (2013.01); C12N 15/1136 (2013.01)] 17 Claims
 
1. A method of treating an angiogenic disease or disorder, comprising administering to a subject in need thereof a vector comprising a polynucleotide encoding a chimeric VEGF-binding protein comprising the amino acid sequence of SEQ ID NO: 3.