US 11,999,730 B1
AKT1 modulators
Michael David Bartberger, Sherman Oaks, CA (US); Elena V. Dneprovskaia, San Diego, CA (US); Yi Fan, San Diego, CA (US); Eric Anthony Murphy, San Marcos, CA (US); and Xuefeng Zhu, San Diego, CA (US)
Assigned to ALTEROME THERAPEUTICS, INC., San Diego, CA (US)
Filed by Alterome Therapeutics, Inc., San Diego, CA (US)
Filed on Sep. 26, 2023, as Appl. No. 18/474,848.
Application 18/474,848 is a continuation in part of application No. PCT/US2023/075058, filed on Sep. 25, 2023.
Claims priority of provisional application 63/582,697, filed on Sep. 14, 2023.
Claims priority of provisional application 63/580,327, filed on Sep. 1, 2023.
Claims priority of provisional application 63/508,418, filed on Jun. 15, 2023.
Claims priority of provisional application 63/498,770, filed on Apr. 27, 2023.
Claims priority of provisional application 63/377,183, filed on Sep. 26, 2022.
Int. Cl. C07D 471/04 (2006.01); C07D 519/00 (2006.01)
CPC C07D 471/04 (2013.01) [C07D 519/00 (2013.01); C07B 2200/05 (2013.01)] 29 Claims
 
1. A compound having the structure of Formula (Ib), or a pharmaceutically acceptable salt or solvate thereof:

OG Complex Work Unit Chemistry
wherein:
Z1 is N, C—H, or C—R3;
Z2 is N, C—H, or C—R4;
Ar is selected from:

OG Complex Work Unit Chemistry
X1 is Nor C—R7;
X2 is N or C—R7;
X3 is N or C—R7;
X4 is N or C—R7;
Y is O, S, or N—R9;
R1 is selected from optionally substituted aryl, or optionally substituted heteroaryl;
R2 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;
R3 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
R4 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
R5 and R6 are each independently hydrogen, deuterium, halogen, —OH, or optionally substituted C1-C6 alkyl; or R5 and R6 together form an oxo; or R5 and R6 join together to form a carbocycle or heterocycle;
each R7 is independently selected from hydrogen, deuterium, halogen, —OH, —SH, optionally substituted C1-C6 alkoxy, —S-(optionally substituted C1-C6 alkyl), —CN, optionally substituted C1-C6 alkyl, and optionally substituted aryl;
L is a divalent radical selected from

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
wherein the asterisk (*) indicates the bond to the —(C(O))q-Ar group:
R8 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C7 cycloalkyl, or optionally substituted heterocyclyl;
R9 is hydrogen, or optionally substituted C1-C6 alkyl;
m is 0, 1, or 2;
n is 1, 2, or 3; and
q is 0 or 1.