CPC C07D 471/04 (2013.01) [C07D 519/00 (2013.01); C07B 2200/05 (2013.01)] | 29 Claims |
1. A compound having the structure of Formula (Ib), or a pharmaceutically acceptable salt or solvate thereof:
wherein:
Z1 is N, C—H, or C—R3;
Z2 is N, C—H, or C—R4;
Ar is selected from:
X1 is Nor C—R7;
X2 is N or C—R7;
X3 is N or C—R7;
X4 is N or C—R7;
Y is O, S, or N—R9;
R1 is selected from optionally substituted aryl, or optionally substituted heteroaryl;
R2 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;
R3 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
R4 is selected from optionally substituted C1-C6 alkyl, or optionally substituted aryl;
R5 and R6 are each independently hydrogen, deuterium, halogen, —OH, or optionally substituted C1-C6 alkyl; or R5 and R6 together form an oxo; or R5 and R6 join together to form a carbocycle or heterocycle;
each R7 is independently selected from hydrogen, deuterium, halogen, —OH, —SH, optionally substituted C1-C6 alkoxy, —S-(optionally substituted C1-C6 alkyl), —CN, optionally substituted C1-C6 alkyl, and optionally substituted aryl;
L is a divalent radical selected from
wherein the asterisk (*) indicates the bond to the —(C(O))q-Ar group:
R8 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C7 cycloalkyl, or optionally substituted heterocyclyl;
R9 is hydrogen, or optionally substituted C1-C6 alkyl;
m is 0, 1, or 2;
n is 1, 2, or 3; and
q is 0 or 1.
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