	US 11,999,712 B1
	2-(benzo[b]thiophen-3-yl)-1-butyl-4,5-diphenyl-1H-imidazole as an anti-inflammatory and anti-microbial compound
Mai Mostafa Khalaf Ali, Al-Ahsa (SA); Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Antar Ahmed Abdelhamid Ahmed, Al-Baha (SA); and Adel A. Marzouk, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Jan. 17, 2024, as Appl. No. 18/415,207.
Application 18/415,207 is a division of application No. 18/242,465, filed on Sep. 5, 2023.
Int. Cl. C07D 401/04 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01)

CPC C07D 401/04 (2013.01) [A61P 31/04 (2018.01); A61P 31/10 (2018.01)]

7 Claims

1. A method of making a 2-(Benzo[b]thiophen-3-yl)-1-butyl-4,5-diphenyl-1H-imidazole compound, the method comprising:

adding benzil, 1-benzothiophene-3-carbaldehyde, ammonium acetate, and n-butylamine to piperidinium hydrogen sulfate in an oil bath to obtain a reaction mixture;

heating the reaction mixture with stirring until reaction completion to obtain a crude product;

purifying the crude product by recrystallization using absolute ethyl alcohol; and

obtaining the 2-(Benzo[b]thiophen-3-yl)-1-butyl-4,5-diphenyl-1H-imidazole compound.