US 11,998,746 B2
System and method for determining a stimulation threshold for closed loop spinal cord stimulation
Wenbo Hou, Santa Clarita, CA (US); Fujian Qu, San Jose, CA (US); Stuart Rosenberg, Woodbury, MN (US); and Kyungmoo Ryu, Palmdale, CA (US)
Assigned to Pacesetter, Inc., Sylmar, CA (US)
Filed by Pacesetter, Inc., Sylmar, CA (US)
Filed on Aug. 24, 2021, as Appl. No. 17/411,017.
Application 17/411,017 is a continuation of application No. 16/359,790, filed on Mar. 20, 2019, abandoned.
Application 16/359,790 is a continuation of application No. 15/345,163, filed on Nov. 7, 2016, granted, now 10,279,182, issued on May 7, 2019.
Prior Publication US 2021/0379385 A1, Dec. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01)
CPC A61N 1/36139 (2013.01) [A61N 1/0551 (2013.01); A61N 1/36071 (2013.01); A61N 1/37247 (2013.01); A61N 1/37264 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method for determining a stimulation threshold for closed loop spinal cord stimulation (SCS), the method comprising:
delivering a series of SCS pulses from at least one lead electrode of a lead coupleable to an implantable pulse generator (IPG) having a processor, the at least one lead electrode configured to be implanted at a target position proximate to or within nerve tissue of interest, the series of SCS pulses configured to form a plurality of SCS waveforms in accordance with SCS therapy parameters;
determining, by the processor, an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy parameters;
increasing, by the IPG, at least one of the SCS therapy parameters;
iteratively repeating the delivering, determining and increasing until the ECAP amplitude exhibits a downward trend divergence; and
defining, by the processor, a stimulation threshold based on the ECAP amplitude at the downward trend divergence.