US 11,998,743 B2
Systems and methods for using electrospinogram signals for closed loop control in Spinal Cord Stimulation therapy
Rosana Esteller, Santa Clarita, CA (US); Tianhe Zhang, Studio City, CA (US); Qi An, Blaine, MN (US); and Gezheng Wen, Shoreview, MN (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Dec. 29, 2020, as Appl. No. 17/137,133.
Claims priority of provisional application 62/976,793, filed on Feb. 14, 2020.
Prior Publication US 2021/0252287 A1, Aug. 19, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); G16H 20/40 (2018.01)
CPC A61N 1/36062 (2017.08) [A61N 1/0551 (2013.01); A61N 1/36132 (2013.01); A61N 1/36139 (2013.01); G16H 20/40 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A method of operating an implantable medical device (IMD) comprising an implantable pulse generator (IPG) and a plurality of electrodes configured to contact a patient's tissue, the method comprising:
providing sub-threshold stimulation at at least one of the electrodes, wherein the stimulation is configured to not evoke paresthesia in the patient;
sensing a stimulation artifact at one or more sensing electrodes, wherein the stimulation artifact comprises a signal formed by an electric field induced in the tissue by the stimulation;
determining at least one stimulation artifact feature of the sensed stimulation artifact;
determining at least one predicted neural feature from the determined at least one stimulation artifact feature using a prediction model that is configured to predict one or more neural features based on one or more stimulation artifact features, wherein the one or more neural features are indicative of a neural response to the stimulation; and
using the determined at least one predicted neural feature to adjust the stimulation.