US 11,998,740 B2
Systems and methods for providing personalized targeted non-invasive stimulation to a brain network
Giacomo Koch, Rome (IT); and Emiliano Santarnecchi, Brookline, MA (US)
Assigned to Sinaptica Therapeutics, Inc., Cambridge, MA (US)
Filed by Sinaptica Therapeutics, Inc., Cambridge, MA (US)
Filed on May 31, 2023, as Appl. No. 18/326,171.
Application 18/326,171 is a continuation of application No. PCT/US2022/036115, filed on Jul. 5, 2022.
Claims priority of provisional application 63/277,086, filed on Nov. 8, 2021.
Claims priority of provisional application 63/218,625, filed on Jul. 6, 2021.
Prior Publication US 2023/0381512 A1, Nov. 30, 2023
Int. Cl. A61N 1/36 (2006.01); A61N 2/00 (2006.01)
CPC A61N 1/36031 (2017.08) [A61N 1/36025 (2013.01); A61N 2/006 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for determining personalized stimulation parameters for non-invasive stimulation of a brain of a subject, the method comprising:
sequentially stimulating using transcranial magnetic stimulation (TMS), each of a plurality of locations within a brain region of the subject, the brain region forming a node of a functional brain network of connected nodes in the brain of the subject;
sensing, using one or more electroencephalography (EEG) electrodes arranged on a scalp of the subject, a plurality of TMS-evoked potentials in response to sequentially stimulating the plurality of locations within the brain region of the subject using TMS; and
determining, based at least in part on at least one characteristic of the plurality of TMS-evoked potentials, personalized stimulation parameters for the subject, wherein the personalized stimulation parameters include a location of stimulation within the brain region and one or more stimulation characteristics, the one or more stimulation characteristics including a personalized intensity of stimulation.