US 11,998,653 B2
Method for treating active bleeding by sequentially applying a biocompatible hemostatic composition and a sealant composition
Xin Ji, Shanghai (CN); Xueshen Shi, Beijing (CN); and Xiaoguang Zhang, Beijing (CN)
Appl. No. 16/959,994
Filed by Beijing Universal Likang Technology Co., LTD., Beijing (CN)
PCT Filed Jan. 10, 2019, PCT No. PCT/CN2019/071108
§ 371(c)(1), (2) Date Jul. 2, 2020,
PCT Pub. No. WO2019/137414, PCT Pub. Date Jul. 18, 2019.
Claims priority of application No. 201810031082.4 (CN), filed on Jan. 12, 2018.
Prior Publication US 2021/0060204 A1, Mar. 4, 2021
Int. Cl. A61L 24/00 (2006.01); A61L 24/04 (2006.01); A61L 24/08 (2006.01); A61L 24/10 (2006.01); C08L 3/02 (2006.01); C08L 5/08 (2006.01); C08L 71/02 (2006.01)
CPC A61L 24/0031 (2013.01) [A61L 24/046 (2013.01); A61L 24/08 (2013.01); A61L 24/106 (2013.01); C08L 3/02 (2013.01); C08L 5/08 (2013.01); C08L 71/02 (2013.01); A61L 2400/04 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of using a biocompatible carboxymethyl starch in combination with a biocompatible polyethylene glycol (PEG) blend to treat a bleeding wound within or on a mammal, comprising:
applying a first amount of said biocompatible carboxymethyl starch to said bleeding wound; and,
applying a second amount of said biocompatible polyethylene glycol (PEG) blend to the bleeding wound, wherein the biocompatible polyethylene glycol (PEG) blend comprises at least one of PEG succinimidyl glutarate blended with PEG thiol, PEG succinimidyl glutarate blended with PEG amine, PEG maleimide blended with PEG thiol, or PEG maleimide blended with PEG amine, wherein the first amount plus the second amount equals a total amount, wherein the first amount is approximately 75% of the total amount, wherein the second amount is approximately 25% of the total amount and wherein said first amount and said second amount in combination are sufficient to cause at least one of: hemostasis in said bleeding wound, wound sealing in said wound, reducing exudation of said bleeding wound, promoting tissue healing of said wound, protecting a surface of said wound, and avoiding infection of said wound.