US 11,998,638 B2
Microparticles comprising PCL and uses thereof
Henderikus Super, Utrecht (NL); Paul Willem Mijnen, Utrecht (NL); Pieter Gerard Zijlstra, Hilversum (NL); and Dirk Wybe Grijpma, Hengelo (NL)
Assigned to AQTIS I.P B.V., Utrecht (NL)
Filed by AQTIS I.P. B.V., Utrecht (NL)
Filed on Dec. 14, 2021, as Appl. No. 17/549,894.
Application 17/549,894 is a continuation of application No. 14/321,392, filed on Jul. 1, 2014, abandoned.
Application 14/321,392 is a continuation of application No. 12/670,518, granted, now 8,795,694, previously published as PCT/NL2008/050506, filed on Jul. 23, 2008.
Claims priority of provisional application 60/952,056, filed on Jul. 26, 2007.
Claims priority of application No. 07113251 (EP), filed on Jul. 26, 2007.
Prior Publication US 2022/0105038 A1, Apr. 7, 2022
Int. Cl. A61K 9/14 (2006.01); A61K 8/02 (2006.01); A61K 8/04 (2006.01); A61K 8/85 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 31/05 (2006.01); A61K 31/167 (2006.01); A61K 31/245 (2006.01); A61K 31/445 (2006.01); A61K 31/765 (2006.01); A61L 27/18 (2006.01); A61L 27/52 (2006.01); A61Q 19/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 9/14 (2013.01) [A61K 8/025 (2013.01); A61K 8/042 (2013.01); A61K 8/85 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 9/1647 (2013.01); A61K 9/5031 (2013.01); A61K 31/05 (2013.01); A61K 31/167 (2013.01); A61K 31/245 (2013.01); A61K 31/445 (2013.01); A61K 31/765 (2013.01); A61L 27/18 (2013.01); A61L 27/52 (2013.01); A61Q 19/00 (2013.01); A61Q 19/08 (2013.01); A61K 9/0019 (2013.01); A61K 2800/412 (2013.01); A61K 2800/54 (2013.01); A61K 2800/654 (2013.01); A61K 2800/91 (2013.01)] 10 Claims
 
1. An implant or filler composition comprising a biodegradable, injectable gel and further comprising microparticles, each microparticle comprising polycaprolactone (PCL) and having:
i) homogenous density and form,
ii) homogenous PCL content throughout the microparticle, and
iii) essentially spherical and smooth surface,
wherein at least 80 weight percent of the microparticles has a diameter distribution range between 25 and 75 μm.