US 11,998,615 B2
Functionalized nanoparticles and their use in treating bacterial infections
Peter Luke Santa Maria, Redwood City, CA (US); and Laurent Bekale, Redwood City, CA (US)
Assigned to The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Filed by The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Filed on Apr. 13, 2022, as Appl. No. 17/719,727.
Claims priority of provisional application 63/174,964, filed on Apr. 14, 2021.
Prior Publication US 2022/0339293 A1, Oct. 27, 2022
Int. Cl. A61K 47/69 (2017.01); A61K 47/60 (2017.01); A61P 31/04 (2006.01)
CPC A61K 47/6929 (2017.08) [A61K 47/60 (2017.08); A61P 31/04 (2018.01)] 23 Claims
 
1. A method of treating an infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a nanoparticle comprising a thiol-binding metallic core conjugated to a fluoroquinolone antibiotic, wherein the diameter of the nanoparticle is in a range from about 1 nm to about 5 nm.