	US 11,998,614 B2
	Compositions and methods for inducing scarring by peri-tumoral cells
Tarun Saxena, Durham, NC (US); Ravi Bellamkonda, Durham, NC (US); and Nassir Mokarram-Dorri, Atlanta, GA (US)
Assigned to DUKE UNIVERSITY, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on Nov. 26, 2019, as Appl. No. 16/696,960.
Claims priority of provisional application 62/771,309, filed on Nov. 26, 2018.
Prior Publication US 2020/0171168 A1, Jun. 4, 2020
Int. Cl. A61K 47/69 (2017.01); A61K 47/65 (2017.01); B82Y 5/00 (2011.01); C07K 14/705 (2006.01)

CPC A61K 47/6929 (2017.08) [A61K 47/65 (2017.08); C07K 14/705 (2013.01); B82Y 5/00 (2013.01)]

10 Claims

1. A composition comprising a conjugate, the conjugate comprising: (1) a gold nanoparticle; (2) optionally, a linker or a masking agent; and (3) a ligand,

wherein the ligand comprises an isolated water-soluble mixture of zymosan polypeptides obtained by extracting zymosan with an extraction buffer comprising CHAPS detergent and applying the CHAPS detergent extract to a 10 kDa centrifugal spin column, and

wherein the conjugate has a diameter of about 50 nm to about 200 nm.