CPC A61K 47/6851 (2017.08) [A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61K 47/6817 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01)] | 15 Claims |
1. An immunoconjugate, comprising:
an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, an N-glycan binding domain and an N-glycan having a structure of formula (1);
![]() wherein “*” represents a bond or a protecting group;
a linker linking to each of the “*” in the N-glycan when “*” presents the bond; and
a payload A and a payload B independently conjugated to the linkers; wherein the payload A and the payload B are the same or different;
wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 11, and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 12.
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