	US 11,998,594 B2
	Anti-cancer plant virus particles linked to HER2 antigens
Nicole F. Steinmetz, San Diego, CA (US); and Sourabh Shukla, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERISTY, Cleveland, OH (US)
Filed on Sep. 30, 2020, as Appl. No. 17/039,312.
Application 17/039,312 is a continuation in part of application No. 16/883,444, filed on May 26, 2020, abandoned.
Application 16/883,444 is a continuation of application No. 16/161,596, filed on Oct. 16, 2018, granted, now 10,660,949, issued on May 26, 2020.
Application 16/161,596 is a continuation of application No. 15/300,931, granted, now 10,098,936, issued on Oct. 16, 2018, previously published as PCT/US2015/024086, filed on Apr. 2, 2015.
Claims priority of provisional application 61/974,053, filed on Apr. 2, 2014.
Prior Publication US 2021/0060147 A1, Mar. 4, 2021
Int. Cl. A61K 39/00 (2006.01); A61K 39/295 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01)

CPC A61K 39/001106 (2018.08) [A61K 39/0011 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/54 (2013.01); A61K 2039/542 (2013.01); C12N 2770/26023 (2013.01); C12N 2770/26043 (2013.01); C12N 2770/26071 (2013.01)]

19 Claims

1. An anti-cancer particle composition comprising an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen, wherein the HER2 antigen comprises all or a portion of the amino acid sequence located between position 163 and 182 of human HER2 protein.