US 11,998,585 B2
Methods and compositions for increasing the dose of a chemotherapeutic agent
D. Travis Wilson, Newton, MA (US)
Assigned to STEALTH BIOTHERAPEUTICS INC., Needham, MA (US)
Filed by Stealth BioTherapeutics Inc., Needham, MA (US)
Filed on Mar. 1, 2022, as Appl. No. 17/684,057.
Application 17/684,057 is a continuation of application No. 16/842,040, filed on Apr. 7, 2020, abandoned.
Application 16/842,040 is a continuation of application No. 16/390,799, filed on Apr. 22, 2019, granted, now 10,646,539, issued on May 12, 2020.
Application 16/390,799 is a continuation of application No. 15/488,697, filed on Apr. 17, 2017, granted, now 10,279,008, issued on May 7, 2019.
Application 15/488,697 is a continuation of application No. 14/388,705, granted, now 9,636,378, issued on May 2, 2017, previously published as PCT/US2013/034647, filed on Mar. 29, 2013.
Claims priority of provisional application 61/618,428, filed on Mar. 30, 2012.
Prior Publication US 2022/0296672 A1, Sep. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/07 (2006.01); A61K 31/137 (2006.01); A61K 31/185 (2006.01); A61K 31/337 (2006.01); A61K 31/366 (2006.01); A61K 31/4245 (2006.01); A61K 31/4748 (2006.01); A61K 31/55 (2006.01); A61K 31/7042 (2006.01); A61K 33/243 (2019.01); A61K 38/08 (2019.01); A61P 25/02 (2006.01)
CPC A61K 38/07 (2013.01) [A61K 31/137 (2013.01); A61K 31/185 (2013.01); A61K 31/337 (2013.01); A61K 31/366 (2013.01); A61K 31/4245 (2013.01); A61K 31/4748 (2013.01); A61K 31/55 (2013.01); A61K 31/7042 (2013.01); A61K 33/243 (2019.01); A61K 38/08 (2013.01); A61P 25/02 (2018.01)] 9 Claims
 
1. A method for increasing the dose of a chemotherapeutic agent in a subject in need thereof, comprising administering to the subject an effective amount of a peptide having the formula Phe-D-Arg-Phe-Lys-NH2, or a pharmaceutically acceptable salt thereof, wherein the peptide treats or prevents one or more dose-limiting neuropathic conditions induced by the chemotherapeutic agent, thereby permitting an increase in the dose of the chemotherapeutic agent.