US 11,998,564 B2
Stable cardioplegic solution for cardiac surgery
Yih-Sharng Chen, Taipei (TW); Li-Jiuan Shen, Taipei (TW); Mei-Hsin Lin, Taipei (TW); and Heng-Wen Chou, Taipei (TW)
Assigned to National Taiwan University, Taipei (TW)
Appl. No. 17/413,567
Filed by National Taiwan University, Taipei (TW)
PCT Filed Dec. 14, 2018, PCT No. PCT/US2018/065581
§ 371(c)(1), (2) Date Jun. 13, 2021,
PCT Pub. No. WO2020/122928, PCT Pub. Date Jun. 18, 2020.
Prior Publication US 2022/0088066 A1, Mar. 24, 2022
Int. Cl. A61K 33/06 (2006.01); A61K 9/08 (2006.01); A61K 31/047 (2006.01); A61K 31/133 (2006.01); A61K 33/04 (2006.01); A61K 33/14 (2006.01)
CPC A61K 33/06 (2013.01) [A61K 9/08 (2013.01); A61K 31/047 (2013.01); A61K 31/133 (2013.01); A61K 33/04 (2013.01); A61K 33/14 (2013.01)] 22 Claims
 
1. A cardioplegic solution comprising potassium (K+), magnesium (Mg2+), sodium (Na+), chloride (Cl−), gluconate, acetate, sulfate (SO42−), tris(hydroxymethyl)aminomethane (THAM) and mannitol dissolved in water, wherein the potassium (K+) concentration is about 27 to about 33 mEq/L, the magnesium (Mg2+) concentration is about 16 to about 20 mEq/L, the sodium (Na+) concentration is about 120 to about 146 mEq/L, the chloride (Cl−) concentration is about 106 to about 130 mEq/L, the gluconate concentration is about 20 to about 24 mmol/L, the acetate concentration is about 22 to about 28 mmol/L, the sulfate (SO42−) concentration is about 6 to about 9 mmol/L, the THAM concentration is between about 5 to about 30 mmol/L, mannitol concentration is about 2 to about 5 g/L and the cardioplegic solution is capable of maintaining a pH of about 8.2 to about 8.6 for 365 days wherein the term “about” as a modifier to a quantity is intended to mean+ or −5% inclusive of the quantity being modified.