US 11,998,563 B2
Polymeric treatment compositions
Gregory M. Cruise, Rancho Santa Margarita, CA (US); Michael J. Constant, Mission Viejo, CA (US); and Joshua Garretson, San Diego, CA (US)
Assigned to MicroVention, Inc., Aliso Viejo, CA (US)
Filed by MicroVention, Inc., Aliso Viejo, CA (US)
Filed on May 13, 2022, as Appl. No. 17/744,192.
Application 15/142,395 is a division of application No. 13/917,323, filed on Jun. 13, 2013, granted, now 9,351,993, issued on May 31, 2016.
Application 17/744,192 is a continuation of application No. 16/806,936, filed on Mar. 2, 2020, granted, now 11,331,340.
Application 16/806,936 is a continuation of application No. 16/232,929, filed on Dec. 26, 2018, granted, now 10,588,923, issued on Mar. 17, 2020.
Application 16/232,929 is a continuation of application No. 15/924,028, filed on Mar. 16, 2018, granted, now 10,201,562, issued on Feb. 12, 2019.
Application 15/924,028 is a continuation of application No. 15/142,395, filed on Apr. 29, 2016, granted, now 9,937,201, issued on Apr. 10, 2018.
Claims priority of provisional application 61/659,916, filed on Jun. 14, 2012.
Prior Publication US 2022/0273700 A1, Sep. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/785 (2006.01); A61K 9/00 (2006.01); A61K 31/78 (2006.01); A61L 24/00 (2006.01); A61L 24/04 (2006.01); A61K 47/32 (2006.01)
CPC A61K 31/785 (2013.01) [A61K 9/0024 (2013.01); A61K 31/78 (2013.01); A61L 24/0089 (2013.01); A61L 24/046 (2013.01); A61K 47/32 (2013.01); A61L 2430/36 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A composition comprising:
a biocompatible polymer comprising:
a first monomer wherein the first monomer is t-butyl acrylate;
a second monomer wherein the second monomer is an alkyl acrylate comprising a hydroxyl group; and
a third monomer wherein the third monomer is hydroxyethyl methacrylate;
a pH-sensitive component, wherein the pH-sensitive component is selected from aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethyl)acrylamide, N-(4-aminobenzyl)acrylamide, N-(2-(4-imidazolyl)ethyl)acrylamide, derivatives thereof, and combinations thereof;
an aqueous solution with a non-physiological pH; and
a visualization agent;
wherein the biocompatible polymer is soluble in the aqueous solution and insoluble at a physiological pH at a treatment site.