US 11,998,560 B2
Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against multidrug and extensively drug-resistant Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates
Frank Schweizer, Winnipeg (CA); Temilolu Idowu, Winnipeg (CA); and Derek Ammeter, Winnipeg (CA)
Assigned to University of Manitoba, Winnipeg (CA)
Appl. No. 17/266,219
Filed by University of Manitoba, Winnipeg (CA)
PCT Filed Nov. 22, 2019, PCT No. PCT/CA2019/051675
§ 371(c)(1), (2) Date Feb. 5, 2021,
PCT Pub. No. WO2020/102910, PCT Pub. Date May 28, 2020.
Claims priority of provisional application 62/770,929, filed on Nov. 23, 2018.
Prior Publication US 2021/0290648 A1, Sep. 23, 2021
Int. Cl. A61K 31/7036 (2006.01); A61K 31/407 (2006.01); A61K 31/427 (2006.01); A61K 31/43 (2006.01); A61K 31/545 (2006.01); A61K 47/54 (2017.01); A61P 31/04 (2006.01); C07H 15/26 (2006.01)
CPC A61K 31/7036 (2013.01) [A61K 31/407 (2013.01); A61K 31/427 (2013.01); A61K 31/43 (2013.01); A61K 31/545 (2013.01); A61K 47/547 (2017.08); A61P 31/04 (2018.01); C07H 15/26 (2013.01)] 12 Claims
 
1. A compound comprising a chemical structure or chemical formula of Formula (A):

OG Complex Work Unit Chemistry
or a suitable salt form thereof, wherein n is a carbon tether having a length of between about 2-18 carbons.