	US 11,998,554 B2
	Composition comprising lipoic acid and vitamin D for the prevention and the treatment of neurodegenerative diseases and peripheral neuropathies
Lorenzo Secondini, Assago (IT)
Assigned to URIACH ITALY S.R.L., Assago (IT)
Appl. No. 17/272,623
Filed by URIACH ITALY S.R.L., Assago (IT)
PCT Filed Sep. 10, 2019, PCT No. PCT/IB2019/057612 § 371(c)(1), (2) Date Mar. 1, 2021, PCT Pub. No. WO2020/053754, PCT Pub. Date Mar. 19, 2020.
Claims priority of application No. 102018000008450 (IT), filed on Sep. 10, 2018.
Prior Publication US 2022/0211724 A1, Jul. 7, 2022
Int. Cl. A61K 31/593 (2006.01); A61K 31/385 (2006.01)

CPC A61K 31/593 (2013.01) [A61K 31/385 (2013.01)]

6 Claims

1. A method for reducing oxidative stress in an astrocyte, comprising administering to the astrocyte a composition comprising a mixture of:

(I) lipoic acid or a derivative thereof, or an acceptable pharmaceutical salt of lipoic acid or a derivative thereof;

(II) a vitamin of group D or a derivative thereof, wherein said (II) vitamin of group D is selected from among: vitamin D3 or a derivative thereof, vitamin D2 or a derivative thereof and a mixture thereof; wherein:

(a) the lipoic acid or a derivative thereof is 98% to 99.9% of the mixture by weight, and

(b) the vitamin D3 and/or vitamin D2, or a derivative thereof, is 0.001% to 1% 0.001% to 10% of the mixture by weight and, optionally, said composition comprises at least one pharmaceutical additive and/or excipient.