US 11,998,539 B2
Substituted aminoquinolones as DGKalpha inhibitors for immune activation
Norbert Schmees, Berlin (DE); Lars Wortmann, Biberbach an der Riß (DE); Dennis Kirchhoff, Berlin (DE); Thi Thanh Uyen Nguyen, Berlin (DE); Nicolas Werbeck, Freiburg (DE); Ulf Bömer, Glienicke (DE); Kirstin Petersen, Berlin (DE); Christina Kober, Lollar (DE); Christian Lechner, Berlin (DE); Dirk Kosemund, Berlin (DE); Rienk Offringa, Heidelberg (DE); Mareike Grees, Berlin (DE); and Benjamin Bader, Berlin (DE)
Assigned to BAYER AKTIENGESELLSCHAFT, Leverkusen (DE); BAYER PHARMA AKTIENGESELLSCHAFT, Berlin (DE); and DEUTSCHES KREBSFORSCHUNGSZENTRUM, Heidelberg (DE)
Filed by Bayer Aktiengesellschaft, Leverkusen (DE); Bayer Pharma Aktiengesellschaft, Berlin (DE); and Deutsches Krebsforschungszentrum, Heidelberg (DE)
Filed on Nov. 30, 2022, as Appl. No. 18/072,490.
Application 18/072,490 is a continuation of application No. 17/780,890, previously published as PCT/EP2020/083198, filed on Nov. 24, 2020.
Claims priority of application No. 19212252 (EP), filed on Nov. 28, 2019; and application No. 20181065 (EP), filed on Jun. 19, 2020.
Prior Publication US 2023/0201186 A1, Jun. 29, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01)
CPC A61K 31/4545 (2013.01) [A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/498 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 37/04 (2018.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A compound having the structure:

OG Complex Work Unit Chemistry
or a hydrate or solvate thereof, or a pharmaceutically acceptable salt of any of the foregoing.