	US 11,998,513 B2
	Two-part nitric oxide generating topical compositions
Joshua C. Doverspike, Ann Arbor, MI (US); James Phan, Lake Orion, MI (US); Jianfeng Wu, Canton, MI (US); Chuanwu Xi, Ann Arbor, MI (US); Yu Qin, Ann Arbor, MI (US); Mark E. Meyerhoff, Ann Arbor, MI (US); and Yang Zhou, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Appl. No. 16/976,382
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Feb. 28, 2019, PCT No. PCT/US2019/019988 § 371(c)(1), (2) Date Aug. 27, 2020, PCT Pub. No. WO2019/169092, PCT Pub. Date Sep. 6, 2019.
Claims priority of provisional application 62/637,008, filed on Mar. 1, 2018.
Prior Publication US 2020/0405658 A1, Dec. 31, 2020
Int. Cl. A61K 31/04 (2006.01); A61K 31/198 (2006.01); A61K 33/30 (2006.01); A61K 38/06 (2006.01); A61K 47/06 (2006.01); B01J 23/72 (2006.01); B01J 31/02 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01)

CPC A61K 31/04 (2013.01) [A61K 31/198 (2013.01); A61K 33/30 (2013.01); A61K 38/063 (2013.01); A61K 47/06 (2013.01); B01J 23/72 (2013.01); B01J 31/0272 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01)]

19 Claims

1. A two-part topical composition, comprising:

a first composition including a S-nitrosothiol nitric oxide donor and a carrier, wherein the carrier includes petroleum jelly; and

a second composition including zinc oxide, the second composition to be mixed with the first composition at a weight ratio of 50:50 to 80:20;

wherein the zinc oxide is to react with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.