US 11,998,482 B2
Method and apparatus for subretinal administration of therapeutic agent
Brendan J. Oberkircher, Cincinnati, OH (US); Daniel W. Price, Loveland, OH (US); Michael F. Keane, Downingtown, PA (US); Saeed Sokhanvar, Belmont, MA (US); Daniel J. Yasevac, Somerville, MA (US); Michel G. Bruehwiler, Newton, MA (US); Leah R. Soffer, Somerville, MA (US); Isaac J. Khan, Bridgewater, NJ (US); Benjamin L Ko, Cincinnati, OH (US); Christopher D. Riemann, Cincinnati, OH (US); and Nathan D. Grubbs, West Chester, OH (US)
Assigned to Gyroscope Therapeutics Limited, London (GB)
Filed by Gyroscope Therapeutics Limited, London (GB)
Filed on Jun. 14, 2021, as Appl. No. 17/346,654.
Application 16/184,221 is a division of application No. 14/619,256, filed on Feb. 11, 2015, granted, now 10,226,379, issued on Mar. 12, 2019.
Application 17/346,654 is a continuation of application No. 16/184,221, filed on Nov. 8, 2018, granted, now 11,058,576.
Claims priority of provisional application 62/104,295, filed on Jan. 16, 2015.
Claims priority of provisional application 62/049,128, filed on Sep. 11, 2014.
Claims priority of provisional application 62/049,100, filed on Sep. 11, 2014.
Claims priority of provisional application 62/049,089, filed on Sep. 11, 2014.
Claims priority of provisional application 62/049,056, filed on Sep. 11, 2014.
Claims priority of provisional application 61/938,956, filed on Feb. 12, 2014.
Prior Publication US 2021/0298951 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 9/00 (2006.01); A61M 5/158 (2006.01)
CPC A61F 9/0017 (2013.01) [A61F 9/0008 (2013.01); A61M 5/158 (2013.01); A61M 2005/1585 (2013.01); A61M 2210/0612 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
(a) a body;
(b) a cannula extending distally from the body along a longitudinal axis, wherein the cannula is flexible, wherein the cannula includes an atraumatic distal end, wherein the atraumatic distal end is configured to provide separation between a choroid and a sclera of an eye of a patient during advancement of the cannula between the choroid and the sclera; and
(c) a needle slidably disposed in the cannula, wherein the needle includes:
(i) a sharp distal tip, wherein the needle is configured to translate relative to the cannula between a proximal position and a distal position, wherein the distal tip is configured to be positioned inside the cannula when the needle is in the proximal position, wherein the distal tip is configured to be positioned outside the cannula when the needle is in the distal position, and
(ii) a pre-bent portion, wherein the pre-bent portion is resiliently biased toward an angled state in which the pre-bent portion is oriented at a predetermined angle relative to the longitudinal axis.