US 11,998,439 B2
Biodegradable vascular grafts
Robert Andrew Allen, Pittsburgh, PA (US); Chelsea Elizabeth Stowell, Pittsburgh, PA (US); and Yadong Wang, Allison Park, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Feb. 18, 2020, as Appl. No. 16/793,355.
Application 16/793,355 is a division of application No. 15/736,728, granted, now 10,603,156, previously published as PCT/US2016/037790, filed on Jun. 16, 2016.
Claims priority of provisional application 62/182,331, filed on Jun. 19, 2015.
Prior Publication US 2020/0179096 A1, Jun. 11, 2020
Int. Cl. A61F 2/07 (2013.01); A61F 2/06 (2013.01); A61L 27/14 (2006.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); D01D 5/00 (2006.01); D01F 11/04 (2006.01); A61L 27/24 (2006.01)
CPC A61F 2/07 (2013.01) [A61F 2/06 (2013.01); A61L 27/14 (2013.01); A61L 27/18 (2013.01); A61L 27/222 (2013.01); A61L 27/507 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); D01D 5/0076 (2013.01); D01D 5/0084 (2013.01); D01F 11/04 (2013.01); A61L 27/225 (2013.01); A61L 27/24 (2013.01); D01D 5/0007 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of fabricating a vascular graft, comprising:
preparing a biodegradable polyester electrospun tubular core;
applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and
surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has a biodegradation rate that is between the biodegradation rate of the polyester electrospun tubular core and the biodegradation rate of the polyester sheath.