US 11,998,330 B2
Interference rejection membranes useful with analyte sensors
Ashwin K. Rao, West Hills, CA (US); Qingling Yang, Northridge, CA (US); Ellis Garai, Studio City, CA (US); and Daniel E. Pesantez, Canoga Park, CA (US)
Assigned to MEDTRONIC MINIMED, INC., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Jan. 29, 2021, as Appl. No. 17/162,885.
Prior Publication US 2022/0240823 A1, Aug. 4, 2022
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 5/7246 (2013.01); A61B 2562/125 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of making an amperometric analyte sensor for implantation within a mammal comprising the steps of:
providing a first base layer;
forming a conductive layer on the first base layer, wherein the conductive layer includes a first working electrode;
forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an enzyme selected to generate a detectable electrical signal upon exposure to an analyte, wherein:
the analyte sensing layer is formed by combining a polymerizable monomer, a crosslinking agent and a photoinitiator agent;
forming an interference rejection layer on the analyte sensing layer, wherein:
the interference rejection layer is formed by a reaction mixture comprising a polymerizable monomer, a crosslinking agent and a photoinitiator agent;
the reaction mixture comprises a 15% to 96% of crosslinker to monomer ratio; and
the analyte sensing layer and the interference rejection layer are formed when the reaction mixture is polymerized by exposure to light; and
forming an analyte modulating layer on the interference rejection layer; such that an amperometric analyte sensor for implantation within a mammal is made.