US 11,998,329 B2
Membrane for continuous analyte sensors
Jonathan Hughes, Carlsbad, CA (US); Robert J. Boock, Carlsbad, CA (US); Chris W. Dring, Fremont, CA (US); Huashi Zhang, San Diego, CA (US); Mark Wu, San Diego, CA (US); and David Sze, San Diego, CA (US)
Assigned to DEXCOM, INC., San Diego, CA (US)
Filed by DexCom, Inc., San Diego, CA (US)
Filed on Aug. 5, 2019, as Appl. No. 16/532,235.
Application 16/532,235 is a continuation of application No. 15/652,663, filed on Jul. 18, 2017, granted, now 10,413,227.
Application 15/652,663 is a continuation of application No. 13/836,530, filed on Mar. 15, 2013, granted, now 9,737,250, issued on Aug. 22, 2017.
Prior Publication US 2019/0357826 A1, Nov. 28, 2019
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 5/14546 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A device for measurement of a concentration of an analyte the device comprising:
a sensor configured to generate a signal indicative of the concentration of the analyte; and
a sensing membrane located over the sensor, the sensing membrane comprising:
an enzyme domain comprising:
an enzyme,
an enzyme stabilizing reagent comprising from 10 wt. % to 50 wt. % of the enzyme wt. % in the enzyme domain,
a base polymer, and
a hydrophilic polymer, wherein the hydrophilic polymer comprises from 5 wt. % to 30 wt. % of the enzyme domain, and
a diffusion resistance domain located more distal to the sensor than the enzyme domain,
wherein the enzyme stabilizing reagent is selected from the group consisting of cocamidopropyl betaine, oleamidopropyl betaine, lauryl sulfobetaine, myristyl sulfobetaine, betaine (trimethylglycine), octyl betaine, phosphatidylcholine, glycine betaine, poly(carboxybetaine)(pCB), poly(sulfobetaine) (pSB), and precursors or derivatives thereof.