US 12,322,584 B2
Apparatus and methods for detection and quantification of elements in molecules
Kaveh Jorabchi, Arlington, VA (US); Joseph Lesniewski, Washington, DC (US); Kunyu Zheng, Washington, DC (US); and Samuel White, Washington, DC (US)
Assigned to Georgetown University, Washington, DC (US)
Appl. No. 17/785,838
Filed by Georgetown University, Washington, DC (US)
PCT Filed Feb. 25, 2021, PCT No. PCT/US2021/019697
§ 371(c)(1), (2) Date Jun. 15, 2022,
PCT Pub. No. WO2021/173853, PCT Pub. Date Sep. 2, 2021.
Claims priority of provisional application 62/983,221, filed on Feb. 28, 2020.
Prior Publication US 2023/0024038 A1, Jan. 26, 2023
Int. Cl. H01J 49/00 (2006.01); G01N 30/72 (2006.01); H01J 49/10 (2006.01); H01J 49/16 (2006.01)
CPC H01J 49/005 (2013.01) [G01N 30/7206 (2013.01); G01N 30/726 (2013.01); G01N 30/7266 (2013.01); H01J 49/0077 (2013.01); H01J 49/105 (2013.01); H01J 49/165 (2013.01); H01J 49/168 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method comprising;
introducing at least one analyte into a gas plasma;
generating neutral species from atoms of the analyte in the gas plasma;
transporting the neutral species downstream of the gas plasma; and
reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source.