US 12,322,497 B2
Emboli detection methods to identify mechanisms of brain injury in susceptible adults and children
Thomas Heldt, Cambridge, MA (US); Syed Muhammad Imaduddin, Cambridge, MA (US); Kerri Larovere, Andover, MA (US); and Barry Kussman, Waban, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Appl. No. 17/601,603
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
PCT Filed Apr. 8, 2020, PCT No. PCT/US2020/027249
§ 371(c)(1), (2) Date Oct. 5, 2021,
PCT Pub. No. WO2020/210344, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/831,678, filed on Apr. 9, 2019.
Prior Publication US 2022/0181008 A1, Jun. 9, 2022
Int. Cl. G16H 30/40 (2018.01); A61B 8/00 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01); G01S 7/52 (2006.01); G01S 15/89 (2006.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01)
CPC G16H 30/40 (2018.01) [A61B 8/06 (2013.01); A61B 8/0808 (2013.01); A61B 8/0891 (2013.01); A61B 8/488 (2013.01); G01S 7/52036 (2013.01); G01S 15/8952 (2013.01); G01S 15/8979 (2013.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
at least one hardware processor; and
at least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by the at least one hardware processor, cause the at least one hardware processor to perform:
obtaining data from an ultrasound signal produced by ultrasound measurements performed on a patient;
computing an embolus-to-blood ratio for the data;
identifying at least one segment of the data as having an embolus-to-blood ratio as being below a detection threshold value, thereby determining at least one background region of the data;
determining, from the at least one background region of the data, a background signal representative of blood flow in the patient, the background signal oscillating over time;
identifying at least one candidate embolic region in the data using the background signal by determining at least one segment of the data as having an embolus-to-blood ratio as being above that of the background signal by at least the threshold detection value;
analyzing the at least one candidate embolic region to generate embolic information; and
outputting the embolic information.