US 12,322,481 B2
Analysis of selectively normalized spatial representations of data
Santiago Gabriel Miriuka, Buenos Aires (AR); and Mark Paul Ramondt, Buenos Aires (AR)
Appl. No. 17/782,344
Filed by Multiplai Health Ltd., Cambridge (GB)
PCT Filed Dec. 4, 2020, PCT No. PCT/IB2020/061534
§ 371(c)(1), (2) Date Jun. 3, 2022,
PCT Pub. No. WO2021/111410, PCT Pub. Date Jun. 10, 2021.
Claims priority of provisional application 62/944,063, filed on Dec. 5, 2019.
Prior Publication US 2023/0005576 A1, Jan. 5, 2023
Int. Cl. G06T 7/00 (2017.01); G16H 10/60 (2018.01)
CPC G16H 10/60 (2018.01) [G06T 7/0012 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computer, comprising:
an interface circuit configured to communicate with an electronic device;
a processor; and
memory configured to store biological data and program instructions, wherein, when executed by the processor, the program instructions cause the computer to analyze the biological data by performing operations comprising:
accessing the biological data in the memory;
transforming the biological data into a spatial representation, wherein the transformation is based at least in part on a predefined relationship between the biological data and corresponding spatial locations in a genome;
selectively normalizing the transformed biological data to obtain normalized transformed data, wherein the selective normalization comprises using a first normalization range for data having a first read count less than a threshold, the first read count being transformed into a first intensity, and using a second normalization range for data having a second read count greater than the threshold, the second read count being transformed into a second intensity;
converting the normalized transformed biological data into an output image, wherein a given pixel in the output image represents a predefined or predetermined range of bases in the genome;
analyzing the image using an image-analysis technique to determine a classification to detect a disease, a trait, a state, a prognosis, a response to treatment, and/or the recurrence of a disease; and
providing, from the interface circuit, the classification addressed to an electronic device.