US 12,322,102 B2
Systems and methods for whole-brain circuit- based neurostimulation to treat brain disorders
Marta Moreno, Hopewell Junction, NY (US)
Assigned to Neurotherapeutix, LLC, Hopewell Junction, NY (US)
Filed by Neurotherapeutix, LLC, Hopewell Junction, NY (US)
Filed on Dec. 19, 2023, as Appl. No. 18/544,777.
Application 18/544,777 is a division of application No. 18/338,221, filed on Jun. 20, 2023, granted, now 11,900,603.
Application 18/338,221 is a continuation of application No. PCT/US2023/068688, filed on Jun. 19, 2023.
Claims priority of provisional application 63/383,241, filed on Nov. 10, 2022.
Claims priority of provisional application 63/354,451, filed on Jun. 22, 2022.
Prior Publication US 2024/0144481 A1, May 2, 2024
Int. Cl. A61N 2/00 (2006.01); G01R 33/48 (2006.01); G01R 33/563 (2006.01); G06T 7/00 (2017.01)
CPC G06T 7/0012 (2013.01) [A61N 2/006 (2013.01); G01R 33/4806 (2013.01); G01R 33/56341 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/30016 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A non-transitory computer-accessible medium having stored thereon computer-executable instructions for selecting one or more brain regions for transcranial magnetic stimulation (TMS) treatment of a patient, wherein the computer-executable instructions are configured when executed by one or more processors to perform a method comprising:
receiving functional magnetic resonance imaging (fMRI) data;
constructing a covariation matrix using the fMRI data;
selecting, using the covariation matrix, a first set of potential targets with stronger covariation values, relative to other brain regions, with a first group of brain regions, selecting a second set of potential targets with weaker covariation values, relative to other brain regions, with a second group of brain regions, or selecting a combination of the first set of potential targets and the second set of potential targets;
receiving diffusion-weighted magnetic resonance imaging (dMRI) data;
using the dMRI data to construct a structural connectivity matrix;
selecting, using the structural connectivity matrix, target regions from the first set of potential targets, the second set of potential targets, or the first and second set of potential targets with a higher number of white matter connections, as compared to other regions, as a target group of brain regions for the TMS treatment, and
stimulating the patient using TMS at one or more target regions in the selected target group of brain regions.