US 12,321,718 B2
True random number generation based on instrument data
Darren Hurley-Smith, Kent (GB); Alastair Droop, York (GB); Remy Lyon, New York, NY (US); and Roxana Iuliana Teodor, York (GB)
Assigned to Veiovia Limited, (GB)
Filed by VEIOVIA LIMITED, York (GB)
Filed on Jan. 12, 2024, as Appl. No. 18/411,503.
Application 18/411,503 is a continuation of application No. 18/448,854, filed on Aug. 11, 2023, granted, now 11,907,686.
Prior Publication US 2025/0053381 A1, Feb. 13, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. G06F 7/58 (2006.01)
CPC G06F 7/588 (2013.01) 19 Claims
OG exemplary drawing
 
1. A computer-implemented method of generating random numbers, comprising:
receiving data output from an instrument characterising macromolecules in a sample, the data including measurement event information relating to measurements of individual macromolecules recorded over time;
determining, for each measurement event in a sequence of measurement events in the data, an event timing (or dwell) representative of the duration of event or the time passing between consecutive events;
comparing data based on each event timing with a comparator value to generate a bit value;
generating data representative of a random number by assembling a vector of bit values determined from the event timings in sequence;
wherein the determined sequence of event timings for the sequence of measurement events represents a source of entropy extracted by the comparison step to generate the random number.