US 12,320,797 B2
System and method for single molecule detection
Stuart Lindsay, Phoenix, AZ (US); Peiming Zhang, Gilbert, AZ (US); and Yanan Zhao, Tempe, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed by ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed on Mar. 13, 2024, as Appl. No. 18/604,115.
Application 18/604,115 is a continuation of application No. 18/178,130, filed on Mar. 3, 2023, granted, now 11,959,905.
Application 18/178,130 is a continuation of application No. 16/917,474, filed on Jun. 30, 2020, granted, now 11,630,098, issued on Apr. 18, 2023.
Application 16/917,474 is a continuation of application No. 16/537,232, filed on Aug. 9, 2019, abandoned.
Application 16/537,232 is a continuation of application No. 15/375,901, filed on Dec. 12, 2016, granted, now 10,379,102, issued on Aug. 13, 2019.
Claims priority of provisional application 62/266,282, filed on Dec. 11, 2015.
Prior Publication US 2024/0345065 A1, Oct. 17, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/327 (2006.01); G01N 33/487 (2006.01)
CPC G01N 33/48721 (2013.01) [G01N 27/3276 (2013.01); G01N 27/3278 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A sensing device for sensing target protein fluctuations, comprising:
a first electrode and a second electrode separated by a gap; and
at least one recognition molecule comprising a first end with a first chemical composition to bind the first electrode or the second electrode, and a second end with a second chemical composition to bind a target protein;
wherein the gap is bridged by the target protein bound by the at least one recognition molecule, wherein a first contact is made with the first electrode via the at least one recognition molecule and a second contact is made with the second electrode, thereby forming a bridge and completing an electrical circuit.