US 12,320,787 B2
Insulated serial column chromatography arrangements and systems
Michael O. Fogwill, Uxbridge, MA (US); Martin Gilar, Franklin, MA (US); Joseph D. Michienzi, Plainville, MA (US); Wade P. Leveille, Douglas, MA (US); Geoff C. Gerhardt, Woonsocket, RI (US); Jeffrey Musacchio, Sharon, MA (US); Jason F. Hill, Milford, MA (US); and Sylvain G. Cormier, Mendon, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on Jun. 22, 2021, as Appl. No. 17/354,296.
Claims priority of provisional application 63/042,378, filed on Jun. 22, 2020.
Prior Publication US 2021/0396722 A1, Dec. 23, 2021
Int. Cl. G01N 30/46 (2006.01); G01N 30/30 (2006.01); G01N 30/32 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/463 (2013.01) [G01N 30/30 (2013.01); G01N 30/32 (2013.01); G01N 2030/025 (2013.01); G01N 2030/027 (2013.01); G01N 2030/3038 (2013.01); G01N 2030/3046 (2013.01); G01N 2030/326 (2013.01); G01N 2030/328 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A chromatography columns arrangement, comprising:
a plurality of chromatography columns arranged in a longitudinally parallel cluster configuration;
a single insulating sleeve which collectively encompasses the chromatography columns in the cluster configuration and provides thermal management of the chromatography columns;
first and second end caps for the chromatography columns arrangements, the endcaps being sized to encompass the plurality of chromatography columns and to interface with the single insulating sleeve to form a sealed container;
an inlet valve for directing mobile phase with a sample of analyte into the cluster configuration, the inlet valve interfaces with the insulating sleeve and integrated into the first end cap for the arrangement;
an outlet valve for directing the mobile phase with the sample of analyte from a selected one of the chromatography columns to an output, the outlet valve interfaces with the insulating sleeve and integrated into the second end cap for the arrangement;
a controller configured for controlling the inlet valve and the outlet valve to serially pass the mobile phase with the sample of analyte through multiple successive ones of the plurality of a sequence of successive ones of the chromatography columns.