US 12,320,747 B2
Apparatus and method for PCR diagnosis based on multi-wavelength light source and orthogonal code signals
Hong-Seok Seo, Daejeon (KR); Dong Hoon Song, Daejeon (KR); Jeong Won Park, Daejeon (KR); and Chul Huh, Daejeon (KR)
Assigned to ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, Daejeon (KR)
Filed by ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, Daejeon (KR)
Filed on Aug. 10, 2022, as Appl. No. 17/884,667.
Claims priority of application No. 10-2021-0152485 (KR), filed on Nov. 8, 2021; and application No. 10-2022-0048415 (KR), filed on Apr. 19, 2022.
Prior Publication US 2023/0141045 A1, May 11, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/552 (2014.01); C12Q 1/686 (2018.01)
CPC G01N 21/554 (2013.01) [C12Q 1/686 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A polymerase chain reaction (PCR) diagnosis apparatus comprising:
a transmitter including a multi-wavelength light source for outputting a first light source signal and a second light source signal having different wavelengths, and configured to apply the first light source signal and the second light source signal to a PCR chip including samples each including a plurality of DNAs;
a code generator configured to generate first code signal and second code signal corresponding to the first light source signal and the second light source signal, respectively, and being orthogonal to each other; and
a receiver including a plurality of detectors with a processor configured to perform a dot product on fluorescent data and each of the first code signal and the second code signal, wherein the fluorescent data include a first fluorescent signal and a second fluorescent signal emitted from a phosphor attached to each of the plurality of DNAs,
wherein the first fluorescent signal is emitted from a first phosphor attached to a first DNA among the plurality of DNAs in response to the first light source signal, and the second fluorescent signal is emitted from a second phosphor attached to a second DNA among the plurality of DNAs in response to the second light source signal.