US 12,319,923 B2
Increasing trichome density and improving transport of metabolites in plant trichomes
Chengalrayan Kudithipudi, Midlothian, VA (US); Yanxin Shen, Henrico, VA (US); Dongmei Xu, Glen Allen, VA (US); Michael Paul Timko, Charlottesville, VA (US); and Roel Rabara, Charlottesville, VA (US)
Assigned to Altria Client Services LLC, Richmond, VA (US); and University Of Virginia Patent Foundation, Charlottesville, VA (US)
Filed by ALTRIA CLIENT SERVICES LLC, Richmond, VA (US); and UNIVERSITY OF VIRGINIA PATENT FOUNDATION, Charlottesville, VA (US)
Filed on Feb. 2, 2022, as Appl. No. 17/591,057.
Claims priority of provisional application 63/145,263, filed on Feb. 3, 2021.
Claims priority of provisional application 63/145,262, filed on Feb. 3, 2021.
Claims priority of provisional application 63/145,259, filed on Feb. 3, 2021.
Prior Publication US 2022/0243216 A1, Aug. 4, 2022
Int. Cl. C12N 15/82 (2006.01); C07K 14/41 (2006.01); C07K 14/415 (2006.01); C12P 5/00 (2006.01)
CPC C12N 15/8262 (2013.01) [C07K 14/415 (2013.01); C12N 15/8223 (2013.01); C12N 15/8243 (2013.01); C12P 5/007 (2013.01); C12N 2800/22 (2013.01)] 17 Claims
 
1. A modified tobacco plant, tobacco seed, or tobacco plant part, comprising a recombinant nucleic acid molecule comprising a nucleic acid sequence encoding an amino acid sequence at least 99% identical to the full length of the amino acid sequence of SEQ ID NO: 18, wherein the nucleic acid sequence is operably linked to a heterologous promoter, and wherein at least one leaf of the modified tobacco plant comprises a greater average trichome density as compared to a leaf of a control tobacco plant grown under comparable conditions.