US 12,319,915 B2
Cytotoxic fluoropyrimidine polymers and methods of use thereof
William H. Gmeiner, Yadkinville, NC (US)
Assigned to Wake Forest University Health Sciences, Winston-Salem, NC (US)
Appl. No. 17/058,989
Filed by Wake Forest University Health Sciences, Winston-Salem, NC (US)
PCT Filed May 24, 2019, PCT No. PCT/US2019/033902
§ 371(c)(1), (2) Date Nov. 25, 2020,
PCT Pub. No. WO2019/226980, PCT Pub. Date Nov. 28, 2019.
Claims priority of provisional application 62/676,511, filed on May 25, 2018.
Prior Publication US 2021/0214730 A1, Jul. 15, 2021
Int. Cl. C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 35/04 (2006.01); C07H 21/04 (2006.01)
CPC C12N 15/1137 (2013.01) [A61K 9/0019 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07H 21/04 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A nucleic acid molecule comprising FdUMP[10] having a polyethylene glycol (PEG) spacer appended to the 5′-terminus and a moiety appended to the 3′-terminus, wherein the moiety is cytosine arabinoside.