US 12,319,907 B2
Composition of culture media for Faecalibacterium prausnitzii
Jae Gu Seo, Gimpo-si (KR); and Do Kyung Lee, Seoul (KR)
Assigned to ENTEROBIOME INC., (KR)
Appl. No. 17/764,371
Filed by ENTEROBIOME INC., Goyang-si (KR)
PCT Filed Feb. 7, 2022, PCT No. PCT/KR2022/001867
§ 371(c)(1), (2) Date Mar. 28, 2022,
PCT Pub. No. WO2023/090536, PCT Pub. Date May 25, 2023.
Claims priority of application No. 10-2021-0159492 (KR), filed on Nov. 18, 2021.
Prior Publication US 2024/0043789 A1, Feb. 8, 2024
Int. Cl. C12N 1/20 (2006.01)
CPC C12N 1/20 (2013.01) 5 Claims
 
1. A medium composition for culturing Faecalibacterium prausnitzii phylogroup II, to a density of 1010 to 1011 CFUs/mL comprising vegetable peptone, yeast extract, a phosphate compound, a carbonate compound, cyanocobalamin, L-cysteine, ammonium acetate, and maltose,
wherein the vegetable peptone is present in an amount of 10-20 g/L, the yeast extract is present in an amount from 5-10 g/L, the phosphate compound is selected from disodium phosphate (Na2HPO4), dipotassium phosphate (K2HPO4) or potassium phosphate (KH2PO4) or mixtures thereof, and is present in an amount to provide a medium composition pH of 6.5 to 8.0, the maltose is present in an amount from 2.5-30 g/L, the carbonate compound is potassium hydrogen carbonate and is present in an amount from 2-6 g/L, and the ammonium acetate is present in an amount from 2-16 g/L.