US 12,319,903 B2
Elastically deformable components and assemblies for use in cellular assays
Kartik Balachandran, Fayetteville, AR (US); and Nasya Moriah Sturdivant, Raleigh, NC (US)
Assigned to THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, Little Rock, AR (US)
Filed by THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, Little Rock, AR (US)
Filed on Jan. 8, 2021, as Appl. No. 17/145,030.
Claims priority of provisional application 62/958,472, filed on Jan. 8, 2020.
Prior Publication US 2021/0238524 A1, Aug. 5, 2021
Int. Cl. C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12N 5/071 (2010.01); C12N 5/079 (2010.01)
CPC C12M 23/34 (2013.01) [C12M 29/04 (2013.01); C12M 35/08 (2013.01); C12N 5/0622 (2013.01); C12N 5/0697 (2013.01); C12N 2502/08 (2013.01); C12N 2502/28 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An elastic assembly for use in a cellular assay, the assembly comprising:
(a) a luminal compartment configured to house a first cell;
(b) an abluminal compartment configured to house a second cell,
(c) an elastic membrane, the elastic membrane comprising a plurality of pores therethrough and configured to separate the luminal compartment from the abluminal compartment;
(d) an anchoring member having a window therethrough mechanically coupled to each of the elastic membrane, the luminal compartment, and the abluminal compartment; and
(e) an actuator mechanically coupled to the anchoring member
wherein each of elastic membrane, the luminal compartment, and the abluminal compartment are capable of elastic deformation when the physiological stress is applied to the anchoring member by the actuator.