US 12,319,828 B2
Surfaces and coating compositions having antifouling, antithrombotic, and antibacterial properties and methods of making
Jason J. Locklin, Bogart, GA (US); Qiaohong Liu, Athens, GA (US); Priyadarshini Singha, Athens, GA (US); Hitesh Handa, Athens, GA (US); Jitendra Pant, Athens, GA (US); Marcus J. Goudie, Athens, GA (US); and Sean P. Hopkins, Athens, GA (US)
Assigned to UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Athens, GA (US)
Filed by University of Georgia Research Foundation, Inc., Athens, GA (US)
Filed on May 13, 2022, as Appl. No. 17/663,296.
Application 17/663,296 is a division of application No. 16/757,701, granted, now 11,370,934, previously published as PCT/US2018/056778, filed on Oct. 19, 2018.
Claims priority of provisional application 62/685,621, filed on Jun. 15, 2018.
Claims priority of provisional application 62/617,418, filed on Jan. 15, 2018.
Claims priority of provisional application 62/575,104, filed on Oct. 20, 2017.
Prior Publication US 2023/0053808 A1, Feb. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C09D 133/10 (2006.01); A61K 31/197 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01)
CPC C09D 133/10 (2013.01) [A61K 31/197 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 2300/21 (2013.01)] 7 Claims
 
1. A method of coating a substrate, comprising:
exposing at least one surface of a NO-donor substrate to a polymer, wherein the polymer has a structure according to the following formula:

OG Complex Work Unit Chemistry
where each occurrence of Z is a zwitterionic moiety:
where, in each instance, either (i) A1 is none and A2 is ═O or (ii) A1 is a covalent bond to the at least one surface of the substrate and A2 is —OH;
where each occurrence of R1 is independently a covalent bond or a linear or branched, substituted or unsubstituted alkyl diradical having from 1 to 12 carbon atoms;
where each occurrence of R2, R3, and R4 is independently a linear or branched, substituted or unsubstituted alkyl having from 1 to 12 carbon atoms; and
where a, b, and c are real number such that 0<a<1, 0≤b<1, 0<c<1, and a+b+c=1, and
exposing the polymer to light energy, thereby causing the polymer to covalently attach to the at least one surface of the NO-donor substrate to form the coating on the NO-donor substrate.