US 12,319,700 B2
Monohydrate potassium salt of a thienopyridone derivative and its preparation process
Sébastien Bolze, Massieux (FR); Marc Lanz, Reitnau (CH); Deniz Arican, Lörrach (DE); Anthony O'Sullivan, Basel (CH); Sophie Hallakou-Bozec, Antony (FR); and Laure Navarre, Lyons (FR)
Assigned to POXEL, Lyons (FR)
Appl. No. 17/293,977
Filed by POXEL, Lyons (FR)
PCT Filed Nov. 18, 2019, PCT No. PCT/EP2019/081650
§ 371(c)(1), (2) Date May 14, 2021,
PCT Pub. No. WO2020/099678, PCT Pub. Date May 22, 2020.
Claims priority of application No. 18306505 (EP), filed on Nov. 16, 2018.
Prior Publication US 2022/0017532 A1, Jan. 20, 2022
Int. Cl. C07D 495/04 (2006.01)
CPC C07D 495/04 (2013.01) 18 Claims
 
1. A process for preparing a monohydrate potassium salt of formula (I):

OG Complex Work Unit Chemistry
said process comprising the steps of:
(A) reacting a compound of formula (II) with potassium carbonate in a solution comprising water and a solvent selected from n-butyl acetate and isopropanol:

OG Complex Work Unit Chemistry
(B) forming a precipitate; and
(C) recovering the precipitate obtained in step (B).