US 12,319,699 B2
L-proline sulfonamide derivatives comprising pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine system, method of manufacturing thereof, uses thereof and pharmaceutical composition comprising the same
Mariusz Mojzych, Siedlce (PL); Katarzyna Kotwica-Mojzych, Lublin (PL); Anna Bielawska, Jurowce (PL); Krzysztof Bielawski, Jurowce (PL); Dariusz Pawlak, Bialystok (PL); Justyna Magdalena Hermanowicz, Bialystok (PL); Anna Tankiewicz-Kwedlo, Bialystok (PL); and Anna Szymanowska, Szczuczyn (PL)
Assigned to UNIWERSYTET MEDYCZNY W BIALYMSTOKU, Bialystok (PL); UNIWERSYTET PRZYRODNICZO-HUMANISTYCZNY W SIEDLCACH, Siedlce (PL); and UNIWERSYTET MEDYCZNY W LUBLINIE, Lublin (PL)
Appl. No. 17/298,088
Filed by UNIWERSYTET MEDYCZNY W BIALYMSTOKU, Bialystok (PL); UNIWERSYTET PRZYRODNICZO-HUMANISTYCZNY W SIEDLCACH, Siedlce (PL); and UNIWERSYTET MEDYCZNY W LUBLINIE, Lublin (PL)
PCT Filed Nov. 27, 2019, PCT No. PCT/PL2019/000110
§ 371(c)(1), (2) Date May 28, 2021,
PCT Pub. No. WO2020/111956, PCT Pub. Date Jun. 4, 2020.
Claims priority of application No. 427991 (PL), filed on Nov. 30, 2018.
Prior Publication US 2022/0017529 A1, Jan. 20, 2022
Int. Cl. C07D 487/14 (2006.01); A61P 35/00 (2006.01)
CPC C07D 487/14 (2013.01) [A61P 35/00 (2018.01)] 15 Claims
 
1. A sulfonamide derivative of 7-methyl-5-phenyl-pyrazolo [4,3-e] tetrazolo [4,5-b][1,2,4]triazine of Formula 1:

OG Complex Work Unit Chemistry
wherein R is L-proline methyl ester or 4-hydroxy-L-proline methyl ester.