US 12,319,692 B2
Anti-influenza virus pyrimidine derivatives
Jian Xiong, Shanghai (CN); Chaofeng Long, Guangzhou (CN); Jingjing Wang, Shanghai (CN); Xiaoxin Chen, Guangzhou (CN); Kevin X Chen, Shanghai (CN); Cheng Xie, Shanghai (CN); Peng Li, Shanghai (CN); Xuanjia Peng, Shanghai (CN); Jian Li, Shanghai (CN); and Shuhui Chen, Shanghai (CN)
Assigned to GUANGDONG RAYNOVENT BIOTECH CO., LTD., Guangzhou (CN)
Filed by GUANGDONG RAYNOVENT BIOTECH CO., LTD., Guangzhou (CN)
Filed on Jun. 19, 2023, as Appl. No. 18/337,329.
Application 17/410,801 is a division of application No. 16/330,353, granted, now 11,136,319, issued on Oct. 5, 2021, previously published as PCT/CN2017/100461, filed on Sep. 5, 2017.
Application 18/337,329 is a continuation of application No. 17/410,801, filed on Aug. 24, 2021, granted, now 11,725,009.
Claims priority of application No. 201610804101.3 (CN), filed on Sep. 5, 2016; and application No. 201611238759.9 (CN), filed on Dec. 28, 2016.
Prior Publication US 2023/0339943 A1, Oct. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/04 (2006.01); A61K 31/506 (2006.01); A61P 31/16 (2006.01); C07D 403/04 (2006.01)
CPC C07D 471/04 (2013.01) [A61K 31/506 (2013.01); A61P 31/16 (2018.01); C07D 403/04 (2013.01); C07B 2200/07 (2013.01)] 17 Claims
 
1. A pharmaceutical composition, comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and an excipient;

OG Complex Work Unit Chemistry
wherein
R1 is selected from C1-6 alkylthio, 5-6 membered heteroaryl, C2-6 alkynyl and C3-6 cycloalkyl, each of which is optionally substituted with 1, 2 or 3 R or R′;
T1 is N;
T2 is N;
R3 is selected from H, halogen, CN, NH2, OH, or from C1-6 alkyl which is optionally substituted with 1, 2 or 3 R or R′;
R is selected from halogen, OH, NH2, CN, COOH,

OG Complex Work Unit Chemistry
 or from C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl, 3-6 membered heterocycloalkyl-C(═O)—, or 3-6 membered heterocycloalkyl-(CH2)t-3—, each of which is optionally substituted with 1, 2 or 3 R′;
R′ is selected from F, Cl, Br, I, CN, OH, NH2, COOH, Me, NHCH3, N(CH3)2,

OG Complex Work Unit Chemistry
 or

OG Complex Work Unit Chemistry
“hetero-” in the 5-6 membered heteroaryl, C1-6 heteroalkyl and 3-6 membered heterocycloalkyl is selected from —N═, —S—, —O—, or —NH—; and
in any one of the aforesaid cases, the number of heteroatom(s) or heteroatomic group(s) is each independently selected from 1, 2 or 3.