US 12,319,666 B2
Hydrate of dimethylaminomicheliolide fumarate and preparation method therefor and use thereof
Zhonghua Li, Tianjin (CN); Junbo Gong, Tianjin (CN); Baohong Hou, Tianjin (CN); Songgu Wu, Tianjin (CN); Yue Chen, Tianjin (CN); Chuanjiang Qiu, Tianjin (CN); Xinghua Zhu, Tianjin (CN); Jie Qi, Tianjin (CN); and Guiyan Wang, Tianjin (CN)
Assigned to ACCENDATECH CO. LTD., Tianjin (CN); and NANKAI UNIVERSITY, Tianjin (CN)
Appl. No. 17/905,127
Filed by ACCENDATECH CO. LTD., Tianjin (CN); and NANKAI UNIVERSITY, Tianjin (CN)
PCT Filed Mar. 26, 2020, PCT No. PCT/CN2020/081349
§ 371(c)(1), (2) Date Aug. 26, 2022,
PCT Pub. No. WO2021/189343, PCT Pub. Date Sep. 30, 2021.
Prior Publication US 2023/0089334 A1, Mar. 23, 2023
Int. Cl. C07D 307/93 (2006.01)
CPC C07D 307/93 (2013.01) [C07B 2200/13 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A hydrate of dimethylaminomicheliolide fumarate, wherein the hydrate is in a crystalline form D, the molar ratio of dimethylaminomicheliolide fumarate to water is 1:1, and the hydrate has a molecular formula of C17H27NO3·C4H4O4·H2O; a thermogravimetric analysis of the hydrate shows a weight loss of 3.97%-4.22% before decomposition; and a differential scanning calorimetry pattern of the hydrate shows a dehydration endothermic peak at 75±5° C. and a characteristic melting peak at 148±5° C.