US 12,319,654 B2
Inert nanocapsules
Paul Lusby, Edinburgh (GB); Michael Burke, Edinburgh (GB); William Grantham, Edinburgh (GB); Steve Archibald, Hull (GB); and Benjamin Burke, Hull (GB)
Assigned to THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, Edinburgh (GB)
Appl. No. 17/260,608
Filed by THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, Edinburgh (GB)
PCT Filed Jul. 15, 2019, PCT No. PCT/GB2019/051972
§ 371(c)(1), (2) Date Jan. 15, 2021,
PCT Pub. No. WO2020/016561, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 1811627 (GB), filed on Jul. 16, 2018.
Prior Publication US 2022/0177431 A1, Jun. 9, 2022
Int. Cl. C07D 213/72 (2006.01); A61K 51/04 (2006.01); C07D 213/22 (2006.01); C07D 213/73 (2006.01)
CPC C07D 213/73 (2013.01) [A61K 51/0474 (2013.01); C07D 213/22 (2013.01)] 20 Claims
 
1. A compound of formula I
[M4L6]·Xn,  (I)
wherein M is a transition metal ion having 6 d-shell valence electrons;
wherein X is a counter ion and n is the number of counterions such that the total charge of the compound of formula I is zero; and
wherein L has formula II

OG Complex Work Unit Chemistry
wherein R1, R2, R3, R6, R7, R8, R9, R10, R13 and R14 are independently H, OR15, OCOR15, OC(O)OR15, OP(O)(OR15)(OR16), OP(O)R15R16, SR15, SCOR15, SC(O)OR15, SP(O)(OR15)(OR16), SP(O)R15R16, NR15R16, NR16COR15, NR16CO2R15 or NR17P(O)(OR15)(OR16);
wherein at least one of R3, R6, R10 and R13 are selected from the group OH, NR15R16 or OR15;
wherein R4 and R5 are H or linked CH groups to form an N, N-phenanthroline ring, and R11 and R12 are H or linked CH groups to form an N,N-phenanthroline ring;
wherein R15, R16 and R17 are independently selected from H and C1-C10 alkyl, polyethylene glycol (PEG) and polyether groups; and
wherein Z is selected from a chemical bond, acetylene, disubstituted phenylene, naphthalene, anthracene, or pyrene.