US 12,319,643 B2
Ionizable compounds and compositions and uses thereof
Roger Adami, Carlsbad, CA (US); Hao Bai, San Diego, CA (US); John Gaudette, Poway, CA (US); Bharat Majeti, San Diego, CA (US); Seiji Nukui, San Diego, CA (US); Kwok Yin Tsang, Irvine, CA (US); Hai Wang, San Diego, CA (US); Haiqing Yin, San Marcos, CA (US); and Wenbin Ying, San Diego, CA (US)
Assigned to Nitto Denko Corporation, Osaka (JP)
Filed by Nitto Denko Corporation, Osaka (JP)
Filed on Apr. 5, 2022, as Appl. No. 17/658,075.
Application 17/658,075 is a continuation of application No. 16/228,054, filed on Dec. 20, 2018, granted, now 11,384,051.
Application 16/228,054 is a continuation of application No. 15/191,511, filed on Jun. 23, 2016, granted, now 10,167,253.
Claims priority of provisional application 62/184,188, filed on Jun. 24, 2015.
Prior Publication US 2022/0242820 A1, Aug. 4, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 271/16 (2006.01); A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 47/16 (2006.01); A61K 47/22 (2006.01); A61K 47/24 (2006.01); C07C 237/08 (2006.01); C07C 237/16 (2006.01); C07C 237/50 (2006.01); C07D 205/04 (2006.01); C07D 207/09 (2006.01); C07D 207/12 (2006.01); C07D 211/74 (2006.01); C07D 211/82 (2006.01); C07D 211/86 (2006.01); C07F 9/06 (2006.01); C07F 9/10 (2006.01)
CPC C07C 271/16 (2013.01) [A61K 9/127 (2013.01); A61K 9/5123 (2013.01); A61K 31/7105 (2013.01); A61K 31/713 (2013.01); A61K 47/16 (2013.01); A61K 47/22 (2013.01); A61K 47/24 (2013.01); C07C 237/08 (2013.01); C07C 237/16 (2013.01); C07C 237/50 (2013.01); C07D 205/04 (2013.01); C07D 207/09 (2013.01); C07D 207/12 (2013.01); C07D 211/74 (2013.01); C07D 211/82 (2013.01); C07D 211/86 (2013.01); C07F 9/06 (2013.01); C07F 9/106 (2013.01)] 12 Claims
 
1. A compound comprising the structure shown in Formula IV

OG Complex Work Unit Chemistry
wherein R1 and R2 are
R1═C(═O)OR4
R2═C(═O)OR5
wherein R4 and R5 are independently for each occurrence a C(12-20) alkyl group, or a C(12-20) alkenyl group:
wherein R3 is selected from

OG Complex Work Unit Chemistry
wherein
each R6 is independently selected from H, alkyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkoxy, and aminoalkyl;
each R7 is independently selected from H, alkyl, hydroxyalkyl, and aminoalkyl;
each R8 is independently selected from H, alkyl, hydroxyalkyl, and aminoalkyl, and any two R8 may form a ring;
q is from zero to four;
Q is O or NR7;
p is from 1 to 4.