US 12,319,641 B2
Lobaric acid derivative having PTP-1B inhibitory activity, preparation method therefor and use thereof
Joung Han Yim, Gyeonggi-do (KR); Il Chan Kim, Gyeonggi-do (KR); Se Jong Han, Gyeonggi-do (KR); Tai Kyoung Kim, Incheon (KR); Dong Gyu Jo, Gyeonggi-do (KR); Hyun Cheol Oh, Jeollabuk-do (KR); Ha Ju Park, Gyeonggi-do (KR); Seul Ki Min, Incheon (KR); Sung Jin Kim, Incheon (KR); Pil Sung Kang, Incheon (KR); Min Ju Kim, Incheon (KR); Jung Eun Kim, Incheon (KR); Kyung Hee Kim, Incheon (KR); and Ju Mi Hong, Incheon (KR)
Assigned to SNBIOSCIENCE INC., Seoul (KR)
Appl. No. 17/637,439
Filed by SNBIOSCIENCE INC., Seoul (KR)
PCT Filed Aug. 14, 2020, PCT No. PCT/KR2020/095109
§ 371(c)(1), (2) Date Feb. 22, 2022,
PCT Pub. No. WO2021/034173, PCT Pub. Date Feb. 25, 2021.
Claims priority of application No. 10-2019-0103206 (KR), filed on Aug. 22, 2019.
Prior Publication US 2022/0281805 A1, Sep. 8, 2022
Int. Cl. C07C 235/84 (2006.01); A61P 3/10 (2006.01); C07D 321/10 (2006.01)
CPC C07C 235/84 (2013.01) [A61P 3/10 (2018.01); C07D 321/10 (2013.01)] 15 Claims
 
1. A lobamide compound, or a salt thereof, represented by Formula 1

OG Complex Work Unit Chemistry
wherein R1 is each independently H, a C1-C10 alkyl group or a C2-C10 allyl group;
R2 is H, a C1-C10 alkyl group, a C2-C10 allyl group, an acyl group, a C1-C10 hydroxyalkyl group or a C1-C10 aminoalkyl group;
R7 is an amide group;
R3 is a carboxylic acid or an amide group;
R4 is a C1-C10 alkoxy group or a hydroxyl group;
R6 is a C1-C10 alkoxy group or a hydroxyl group; and
R5 is a C1-C10 alkoxy group or a hydroxyl group.