US 12,318,633 B2
Determining uncertainty in radiation therapy delivered dose accumulation
Tomasz Morgas, Basel (CH); Tobias Gass, Vogelsang AG (CH); Thomas Coradi, Lenzburg (CH); Fernando Franco, Zurich (CH); and Michael Waschbüesch, Rheinfelden (CH)
Assigned to SIEMENS HEALTHINEERS INTERNATIONAL AG, (CH)
Filed by SIEMENS HEALTHINEERS INTERNATIONAL AG, Steinhausen (CH)
Filed on Mar. 31, 2022, as Appl. No. 17/710,975.
Prior Publication US 2023/0310896 A1, Oct. 5, 2023
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1071 (2013.01) 20 Claims
OG exemplary drawing
 
1. A computer-implemented method of generating dose information for a region of patient anatomy, the method comprising:
determining a first set of dose values for a day-of-treatment three-dimensional (3D) image of the region, wherein each value in the first set of dose values is associated with a different voxel of the first 3D image, and wherein the day-of-treatment 3D image is associated with a specific application of dose to the region for a treatment fraction;
determining a second set of dose values for a representative 3D image of the region, wherein the representative 3D image corresponds to a treatment planning image of the region obtained prior to the day-of-treatment 3D image, and each value in the second set of dose values is associated with a different voxel of the representative 3D image;
determining a set of geometric error models for the representative 3D image of the region, wherein each geometric error model in the set of geometric error models indicates a geometric error between a voxel of the representative 3D image and one or more voxels of the day-of-treatment 3D image of the region for the treatment fraction;
based on the second set of dose values and the set of geometric error models, determining a set of dose probability values for each voxel of the representative 3D image, wherein each set of dose probability values includes at least one dose value and a probability value that a voxel of the representative 3D image corresponds to the dose value; and
presenting a delivered dose distribution for a portion of the representative 3D image and uncertainty information associated with the delivered dose distribution to a clinician, wherein the uncertainty information is based on the sets of dose probability values.