| CPC A61M 5/1723 (2013.01) [A61M 5/14248 (2013.01); A61M 5/158 (2013.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01); G16H 50/30 (2018.01); A61M 2005/14208 (2013.01); A61M 2005/14268 (2013.01); A61M 5/1452 (2013.01); A61M 2005/1586 (2013.01); A61M 2205/3313 (2013.01); A61M 2205/3569 (2013.01); A61M 2205/502 (2013.01); A61M 2230/201 (2013.01)] | 40 Claims |

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1. A method of delivering insulin, the method comprising:
generating an indication that a probability of occurrence of an undesirable event exceeds a threshold responsive to a prediction by an event model; and
generating a recommended change to a personalization setting of an insulin therapy responsive to the indication,
wherein the event model is configured to predict an occurrence of the undesirable event responsive to a difference between a personalized model that represents a user's physiological response to insulin therapy and a generalized model that represents a generalized physiological response by a general population to an insulin therapy.
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